Vagal CNP Heart-rate Set-point
Endogenous C-type natriuretic peptide (CNP) / NPR-B signaling as a super-slow paracrine set-point modulator of the sino-atrial node, and a stabilized CNP analog peptide (VLADOS-2) to durably lower resting heart rate without the negative inotropy of beta-blockade. Field: cardiovascular peptide pharmacology / autonomic regulation.
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Endogenous C-type natriuretic peptide (CNP) / NPR-B signaling as a super-slow paracrine set-point modulator of the sino-atrial node, and a stabilized CNP analog peptide (VLADOS-2) to durably lower resting heart rate without the negative inotropy of beta-blockade. Field: cardiovascular peptide pharmacology / autonomic regulation.Team
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